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Quality and Replication of Microarray StudiesVolume 8, Number 5, September 2012 - SC 25 - pp. 578-582JUSTIN R CHIMKA, JING WU and QIN HONGDepartment of Industrial Engineering, University of ArkansasFayetteville, AR 72701, USA (Received on May 11, 2010, revised on July 26 and August 20, 2010, and June 30, 2012) Abstract:Quality assessment of DNA microarrays uses different spot parameters that contain complete information to describe each microarray and detect corrupted spots. Images obtained through replication should result in improved quality as measured according to parameters. We propose methods to determine the number of replicates required to achieve a certain level of quality, and present an application to the parameter known as Background.
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